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1.
PLoS One ; 19(3): e0299868, 2024.
Article in English | MEDLINE | ID: mdl-38489308

ABSTRACT

We investigated the social, emotional, and cognitive predictors of adherence to four health behaviors (handwashing, mask wearing, social contact limitations, and physical distancing) during one critical phase of the COVID-19 pandemic. We collected data (N = 5803, mean age = 53; 57% women) in Belgium at five time points between April and July 2021, a time during which infections evolved from high (third wave of the pandemic) to low numbers of COVID-19 cases. The results show that the social, emotional, and cognitive predictors achieved high levels of explained variance (R2 > .60). In particular, the central components of behavioral change (attitudes, intentions, control, habits, norms, and risk) were the strongest and most consistent predictors of health behaviors over time. Likewise, autonomous motivation and empathetic emotions (e.g., attentive, compassionate) had a positive impact on health behavior adherence, whereas it was the opposite for lively emotions (e.g., active, enthusiastic). These results offer policymakers actionable insights into the most potent and stable factors associated with health behaviors, equipping them with effective strategies to curtail the spread of future infectious diseases.


Subject(s)
COVID-19 , Humans , Female , Middle Aged , Male , COVID-19/epidemiology , Pandemics , SARS-CoV-2 , Longitudinal Studies , Health Behavior
2.
BMC Public Health ; 24(1): 731, 2024 Mar 06.
Article in English | MEDLINE | ID: mdl-38448885

ABSTRACT

BACKGROUND: People's perceived risk of being infected and having severe illness was conceived as a motivational source of adherence to behavioral measures during the COVID-19 crisis. METHODS: We used online self-reported data, spanning 20 months of the COVID-19 crisis in Belgium (n = 221,791; 34.4% vaccinated; July 2020 - March 2022) to study the association between risk perception and motivation. RESULTS: Both perceived infection probability and severity fluctuated across time as a function of the characteristics of emerging variants, with unvaccinated persons perceiving decreasingly less risk compared to vaccinated ones. Perceived severity (and not perceived probability) was the most critical predictor of autonomous motivation for adherence to health-protective measures, a pattern observed at both the between-day and between-person level among both vaccinated and unvaccinated individuals. An integrated process model further indicated that on days with higher hospitalization load, participants reported being more adherent because risk severity and autonomous motivation for adherence were more elevated on these days. CONCLUSIONS: These findings suggest that risk severity served as a critical and dynamic resource for adherence to behavioral measures because it fostered greater autonomous regulation.


Subject(s)
COVID-19 , Motivation , Humans , COVID-19/epidemiology , COVID-19/prevention & control , Pandemics/prevention & control , Vaccination , Perception
3.
PLoS One ; 19(2): e0297887, 2024.
Article in English | MEDLINE | ID: mdl-38394248

ABSTRACT

Previous research shows that stereotypes can distort the visual representation of groups in a top-down fashion. In the present endeavor, we tested if the compensation effect-the negative relationship that emerges between the social dimensions of warmth and competence when judging two social targets-would bias the visual representations of these targets in a compensatory way. We captured participants' near spontaneous facial prototypes of social targets by means of an unconstrained technique, namely the reverse correlation. We relied on a large multi-phase study (N = 869) and found that the expectations of the facial content of two novel groups that differed on one of the two social dimensions are biased in a compensatory manner on the facial dimensions of trustworthiness, warmth, and dominance but not competence. The present research opens new avenues by showing that compensation not only manifests itself on abstract ratings but that it also orients the visual representations of social targets.


Subject(s)
Facial Recognition , Social Perception , Humans
4.
Cogn Emot ; 38(1): 103-119, 2024 Feb.
Article in English | MEDLINE | ID: mdl-37882199

ABSTRACT

Research has suggested an increase in loneliness during the COVID-19 pandemic, but much of this work has been cross-sectional, making causal inferences difficult. In the present research, we employed a longitudinal design to identify loneliness trajectories within a period of twelve months during the COVID-19 pandemic in Belgium (N = 2106). We were particularly interested in the potential protective role of self-compassion in these temporal dynamics. Using a group-based trajectory modelling approach, we identified trajectory groups of individuals following low (11.0%), moderate-low (22.4%), moderate (25.7%), moderate-high (31.3%), and high (9.6%) levels of loneliness. Findings indicated that younger people, women, and individuals with poor quality relationships, high levels of health anxiety, and stress related to COVID-19, all had a higher probability of belonging to the highest loneliness trajectory groups. Importantly, we also found that people high in two of the three facets of self-compassion (self-kindness and common humanity) had a lower probability of belonging to the highest loneliness trajectory groups. Ultimately, we demonstrated that trajectory groups reflecting higher levels of loneliness were associated with lower life satisfaction and greater depressive symptoms. We discuss the possibility that increasing self-compassion may be used to promote better mental health in similarly challenging situations.


Subject(s)
COVID-19 , Humans , Female , Cross-Sectional Studies , Loneliness , Pandemics , Self-Compassion , Depression
5.
Psychol Health ; : 1-28, 2023 Nov 20.
Article in English | MEDLINE | ID: mdl-37981782

ABSTRACT

AIM: This study aimed to investigate the associations between health behavior adherence and psychological factors during the COVID-19 pandemic, with a particular focus on identifying trajectories of handwashing, mask wearing, social contact limitations, and physical distancing. METHODS: We employed a multi-trajectory group-based approach to analyze data from 6026 Belgian residents, including 60% women, with an average age of 52.65. Data were collected over six waves spanning from April 2021 to December 2021. RESULTS: Participants were categorized into trajectory groups based on persistently low (11.9%), moderate-low (20.9%), moderate-high (39.1%), and high (28.1%) levels of adherence to the specified health behaviors. Our findings indicate a declining trend in health behavior adherence over the study period. Additionally, we observed that females, older individuals, and those with prior COVID-19 infection had a higher likelihood of belonging to trajectory groups characterized by the highest levels of health behavior adherence. Similarly, individuals with positive vaccination intentions, a heightened perception of consequences, and increased health anxiety demonstrated greater adherence to health behaviors over time. Furthermore, our investigation into the relationship between health behaviors and mental health revealed that participants in trajectory groups with higher levels of adherence to social contact limitations and physical distancing reported increased feelings of loneliness and decreased life satisfaction. CONCLUSIONS: The COVID-19 pandemic has reshaped our lives, and while vaccines have marked progress, maintaining health behaviors is crucial for virus prevention. To address potential mental health challenges from sanitary measures, policies and communication should promote health behaviors while acknowledging their psychological impact.

6.
Article in English | MEDLINE | ID: mdl-37985398

ABSTRACT

The essential role of the psychological needs for autonomy, competence, and relatedness in well-being has been demonstrated convincingly. Yet whether their fulfillment also serves as a source of resilience in the face of adversity has received limited attention. A longitudinal sample of Belgian citizens (N = 1869; Mage = 56.23, 68% female) completed an online questionnaire on 13 occasions between April 2020 and April 2022 during the COVID-19 crisis. Multilevel analyses showed that need fulfillment, both at the between- and within-person level, related negatively to concerns, even after controlling for exposure to personal risks. Further, the association between concerns and changes in symptoms of depression and anxiety was dampened when people reported higher need fulfillment compared with others (i.e. between-person level) or when they reported periodically more need fulfillment than usual (i.e. within-person level). This moderation effect occurred on top of the systematic negative main effect of need fulfillment on symptoms of anxiety and depression. Psychological need fulfillment serves as a resilience factor (a) by reducing concerns in the face of adverse events (i.e. an appraisal effect) and (b) by mobilizing resources that help individuals to deal better with concerns (i.e. a coping effect). Theoretical and practical implications of the resilience effect of need fulfillment are discussed.

7.
Appl Psychol Health Well Being ; 15(4): 1293-1318, 2023 11.
Article in English | MEDLINE | ID: mdl-36748440

ABSTRACT

The transmissibility of new COVID-19 variants and decreasing efficacy of vaccines led authorities to recommend a booster and even an annual dose. However, people's willingness to accept new doses varied considerably. Using two independent longitudinal samples of 4596 (Mean age = 53.6) and 514 (Mean age = 55.9) vaccinated participants, we examined how people's (lack of) vaccination motivation for their first dose was associated with their intention to get a booster (Sample 1) and an annual dose (Sample 2) several months later (Aim 1). We also aimed to capture the impact of the motivational heterogeneity on these intentions by capitalizing on participants' different motivational profiles collected at baseline (Aim 2). Across both samples, autonomous motivation, controlled motivation, and distrust-based amotivation were uniquely related to, respectively, higher, lower, and even lower booster and annual dose intentions. Further, a two-step clustering procedure revealed five profiles, with the profiles characterized by higher autonomous motivation (i.e. Good Quality and High Quantity profiles) reporting the highest vaccination intentions and the profile characterized by the highest number of obstacles (i.e. Global Amotivated profile) yielding the lowest vaccination intentions. These results stress the critical need to support citizens' volitional endorsement of vaccination to harvest long-term benefits with respect to COVID-19.


Subject(s)
COVID-19 , Intention , Humans , Middle Aged , Motivation , COVID-19/prevention & control , Group Processes
8.
Psychol Belg ; 63(1): 1-15, 2023.
Article in English | MEDLINE | ID: mdl-36643577

ABSTRACT

To limit the spread of COVID-19, public authorities have recommended sanitary behaviors such as handwashing, mask-wearing, physical distancing, and social distancing. We recruited a large sample of higher education students in Belgium (N = 3201-3441) to investigate the role of sociodemographic variables, mental health, previous COVID-19 infections, academic involvement, and risk perception on adherence to these sanitary behaviors. This cross-sectional study took place during the second COVID-19 wave in Belgium, between February and March 2021. Analyses showed that living alone, being female, later in the academic curriculum, having higher general and health anxiety, higher academic involvement, and higher risk perception were positively associated with adherence to the four aforementioned sanitary behaviors. Conversely, previous infection with COVID-19 and having been quarantined were negative predictors. Our results show a set of predictors highly similar for the four sanitary behaviors. We discuss potential initiatives to increase adherence to sanitary behaviors in this group of highly educated youngsters.

9.
Health Commun ; 38(13): 2894-2903, 2023 12.
Article in English | MEDLINE | ID: mdl-36162986

ABSTRACT

This vignette-based study examined in a sample of unvaccinated Belgian citizens (N = 1918; Mage = 45.99) how health care workers could foster reflection about and intentions to get vaccinated against COVID-19 by experimentally varying their communication style (i.e., autonomy-supportive vs. controlling) and the reference to external motivators (i.e., use of a monetary voucher or corona pass vs. the lack thereof). Each participant was randomly assigned to one of six conditions and rated a vignette in terms of anticipated autonomy satisfaction, perceived effectiveness, reflection, and vaccination intention. An autonomy-supportive, relative to a controlling, communication style predicted greater autonomy need satisfaction, which in turn related positively to perceived effectiveness, reflection, and vaccination intention. External motivators failed to generate positive effects compared to the control condition. The findings highlight the critical role of autonomy support in promoting a self-endorsed decision to get vaccinated.


Subject(s)
Intention , Personal Autonomy , Humans , Middle Aged , Communication , Vaccination , Personal Satisfaction
10.
Health Psychol ; 42(2): 113-123, 2023 Feb.
Article in English | MEDLINE | ID: mdl-36074600

ABSTRACT

OBJECTIVE: Across nationwide rollout of COVID-19 vaccination, people in Belgium differed widely in their vaccination intention. In the present study, we examined (a) how people's vaccination intentions changed during the vaccination rollout and (b) whether changes in motivation (i.e., autonomous, controlled, and distrust-based (a)motivation) predicted changes in vaccination intention, thereby taking into account people's vaccination intention at baseline. METHOD: Using 4 subsamples of participants who were vaccinated at different time points (ntotal = 10,799) between December 2020 and June 2021; we used latent change modeling and latent growth curve modeling to examine the associations among initial levels and changes in vaccination motivation and vaccination intention. RESULTS: Across subsamples, changes in vaccination intention were found to be qualified by changes in motivation. An increase in autonomous motivation was related to a positive shift in vaccination intention, while an increase in both controlled motivation and distrust-based amotivation was related to a negative shift in vaccination intention. Moreover, autonomous motivation predicted especially an increase in vaccination intention among those initially low in vaccination intention, whereas an increase in either controlled motivation or distrust-based amotivation especially predicted a decrease in vaccination intention among those initially high in vaccination intention. CONCLUSIONS: Findings suggest that a growing sense of ownership and a reduction in distrust is critical for individuals to develop a stronger intention to get vaccinated, particularly when people had initially low vaccination intentions. We discuss conceptual, methodological, and practical implications. (PsycInfo Database Record (c) 2023 APA, all rights reserved).


Subject(s)
COVID-19 , Intention , Humans , Motivation , COVID-19 Vaccines , COVID-19/prevention & control , Vaccination/psychology
11.
Int J Health Policy Manag ; 12: 8021, 2023.
Article in English | MEDLINE | ID: mdl-38618783

ABSTRACT

BACKGROUND: The stringency of the measures taken by governments to combat the COVID-19 pandemic varied considerably across countries and time. In the present study, we examined how the proportionality to the epidemiological situation is related to citizens'behavior, motivation and mental health. METHODS: Across 421 days between March 2020 and March 2022, 273,722 Belgian participants (Mage = 49.47; 63.9% female; 33% single) completed an online questionnaire. Multiple linear mixed regression modeling was used to examine the interaction between the epidemiological situation, as indicated by the actual hospitalization numbers, and the stringency index to predict day-to-day variation in the variables of interest. RESULTS: Systematic evidence emerged showing that disproportional situations, as opposed to proportional situations, were associated with a clear pattern of maladaptive outcomes. Specifically, when either strict or lenient measures were disproportional in relation to the epidemiological situation, people reported lower autonomous motivation, more controlled motivation and amotivation, less adherence to sanitary rules, higher perceived risk of infection, lower need satisfaction, and higher anxiety and depressive symptoms. Perceived risk severity especially covaried with the stringency of the measures. At the absolute level, citizens reported the highest need satisfaction and mental health during days with proportional lenient measures. CONCLUSION: Stringent measures are not per se demotivating or compromising of people's well-being, nor are lenient measures as such motivating or enhancing well-being. Only proportional measures, that is, measures with a level of stringency that is aligned with the actual epidemiological situation, are associated with the greatest motivational, behavioral, and mental health benefits.


Subject(s)
COVID-19 , Motivation , Humans , Female , Middle Aged , Male , Pandemics , COVID-19/epidemiology , COVID-19/prevention & control , Government , Hospitalization
12.
Health Psychol Behav Med ; 10(1): 855-870, 2022.
Article in English | MEDLINE | ID: mdl-36147293

ABSTRACT

BACKGROUND: Using a longitudinal design, we investigate how the adherence to handwashing and its underlying socio-psychological predictors evolved over time during the COVID-19 pandemic and under distinct circumstances (e.g. when the crisis was more acute or chronic). METHOD: We collected data (N = 753) in Belgium and France at the onset of the COVID-19 pandemic when the crisis was at its peak (April 2020), and almost a year later (February 2021), when the outbreak was more manageable. RESULTS: Regression models suggest that the compliance with handwashing and its pattern of underlying predictors remained remarkably stable over time despite the variations in contextual factors such as the severity of the health crisis and the stringency of health measures. As such, the findings also highlight the robustness of the models that predict it, namely the Theory of Planned Behavior. The intentions to perform the behavior, the perceived control over it, and being part of the (para)medical field were among the strongest predictors. CONCLUSIONS: In practice, the stability of the underlying factors suggests a set of action levers that can be used in communication campaigns aimed at fostering its adherence throughout the pandemic.

13.
Expert Rev Vaccines ; 21(10): 1475-1485, 2022 10.
Article in English | MEDLINE | ID: mdl-35876102

ABSTRACT

BACKGROUND: This vignette study explores which factors contribute to higher COVID-19 vaccination intentions. METHODS: Between the 4th-11 January 2021, we recruited 15,901 Belgian citizens (Mage = 50.11 years, range 18-100) through convenience sampling to participate in a vignette study. In each vignette, we manipulated contextual determinants consisting of different factors. Each participant rated six vignettes in terms of the outcomes 'vaccination intention' and 'recommendation to others.' Finally, we explored the benefits of tailored communication by examining whether these ratings depended upon citizens' initial motives for vaccination. RESULTS: Participants are most likely to accept a vaccine when they expect no or only small side effects, when the vaccine offers a 95% protection, and when people can no longer infect others (p < 0.001). The possibility to receive the vaccine at home or at the GP's office, highlighting that most citizens are willing to get vaccinated, and emphasizing the protective benefits for others yielded additional positive effects (p < 0.001). Results showed that tailored communication has a small but significant effect, especially for individuals high on distrust-based amotivation (p < 0.01). CONCLUSION: In addition to vaccine characteristics, there is room for policymakers to respond to those determinants that fall under their control and can thus be highlighted within communication campaigns.


Subject(s)
COVID-19 Vaccines , COVID-19 , Adolescent , Adult , Aged , Aged, 80 and over , Humans , Intention , Middle Aged , Vaccination , Young Adult
14.
Soc Sci Med ; 301: 114926, 2022 05.
Article in English | MEDLINE | ID: mdl-35344775

ABSTRACT

RATIONALE: Vaccination willingness is a critical step in the effort to reach herd immunity and control the COVID-19 pandemic. Nevertheless, many people remain reluctant to be vaccinated. OBJECTIVE: Integrating the literature on Self-Determination Theory, trust in authorities, and conspiracy theories, this research examines (a) the direct and indirect effect of government trust and conspiracism via underlying forms of motivations for (not) getting vaccinated against COVID-19 and (b) whether these associations differ across the two largely politically independent Belgian linguistic groups. METHODS: Using Structural Equation Modeling, we tested our models in two independent samples, in February 2021 (T1) and April 2021 (T2) (Total N = 8264). RESULTS: At T1 and T2, Government trust and conspiracism both predict COVID-19 vaccination intention, respectively positively and negatively. These relations are fully mediated by motivational factors, with identified motivations having a larger positive contribution. Looking at linguistic context, differences emerge at T2, with French-speaking Belgians showing lower levels of government trust and higher levels of conspiracism than Dutch speakers. CONCLUSIONS: Results highlight the importance of integrating distal (trust in government, conspiracism) and proximal (motivational) variables to understand vaccination intentions.


Subject(s)
COVID-19 , Intention , COVID-19/prevention & control , COVID-19 Vaccines/therapeutic use , Government , Humans , Motivation , Pandemics/prevention & control , Trust , Vaccination
15.
J Health Psychol ; 27(14): 3097-3105, 2022 12.
Article in English | MEDLINE | ID: mdl-35297292

ABSTRACT

The objective of the current research was to investigate how a series of psychological factors may underlie two COVID-19 health behaviors, and how a contextual factor (country of residence) could shape their influence. Cross-sectional results from the first pandemic wave (NBelgium = 4878, NFrance = 1071) showed that handwashing and social contacts limitation are predicted by a unique set of psychological variables that holds across Belgium and France, despite their distinct lockdown-policies strictness. In practice, policy-makers could leverage on these unique predictors and fine-tune their strategies accordingly to promote adherence to each measure while generalizing it across similar nations.


Subject(s)
COVID-19 , Humans , Pandemics , SARS-CoV-2 , Cross-Sectional Studies , Belgium/epidemiology , Communicable Disease Control , Health Behavior
16.
Vaccine ; 40(2): 288-297, 2022 01 21.
Article in English | MEDLINE | ID: mdl-34961635

ABSTRACT

The present research examined which motivational factors contribute to individuals' intention to take a vaccine that protects against SARS-CoV-2-virus and their self-reported vaccine uptake several months later. The role of different types of motivation was investigated (i.e., autonomous and controlled regulation) as well as vaccine distrust and effort to obtain a vaccine. Across two large-scale cross-sectional (N = 8887) and longitudinal (N = 6996) studies and controlling for various covariates, autonomous motivation and distrust-based amotivation contributed positively and negatively, respectively, to a) concurrent vaccination intentions, b) self-reported vaccination and c) subsequent subscription to a waitlist to obtain a vaccine. Participants' infection-related risk perception predicted more positive vaccination outcomes through fostering greater autonomous motivation for vaccination and lower distrust, whereas pandemic-related health concerns failed to yield such adaptive effects. The results emphasize the importance of fostering autonomous motivation for vaccination and handling distrust.


Subject(s)
COVID-19 , Vaccines , COVID-19 Vaccines , Cross-Sectional Studies , Humans , Intention , Motivation , SARS-CoV-2 , Vaccination
17.
PLoS One ; 16(11): e0258320, 2021.
Article in English | MEDLINE | ID: mdl-34735473

ABSTRACT

The COVID-19 pandemic presents a global crisis and authorities have encouraged the population to promote preventive health behaviors to slow the spread of the virus. While the literature on psychological factors influencing health behaviors during the COVID-19 is flourishing, there is a lack of cross-national research focusing on multiple health behaviors. The present study overcomes this limitation and affords a validation of the Theory of Planned Behavior (TPB) as a conceptual framework for explaining the adoption of handwashing and limitation of social contacts, two health behaviors that highly differ in their nature. Specifically, we compare TPB model on these two protective behaviors among people living in Belgium (N = 3744) and France (N = 1060) during the COVID-19 sanitary crisis. Data were collected from March 18 until April 19, 2020, which corresponds to the spring lockdown and the first peak of the pandemic in these countries. Results indicated that more positive attitudes, greater social norms, increased perceived control and higher intentions were related to higher adherence to handwashing and limitation of social contacts, for both Belgian and French residents. Ultimately, we argued that the TPB model tends to manifest similarly across countries in explaining health behaviors, when comparing handwashing and limitation of social contacts among individuals living in different national contexts.


Subject(s)
COVID-19/epidemiology , Health Behavior , Social Behavior , Adult , Belgium/epidemiology , Communicable Disease Control , Female , France/epidemiology , Hand Disinfection , Health Communication , Humans , Intention , Male , Middle Aged , Models, Theoretical , Pandemics , Psychological Theory , SARS-CoV-2
18.
J Pers Soc Psychol ; 120(5): 1146-1174, 2021 May.
Article in English | MEDLINE | ID: mdl-34180688

ABSTRACT

The literature on the approach/avoidance training (AAT) effect has focused on its evaluative consequences (with approached stimuli evaluated as more positive than avoided ones). Building on a grounded cognition framework, we investigated AAT effects on the visual representation of stimuli (here, neutral faces). We formulated specific predictions regarding the facial features that should be the most biased and the conditions under which the effect should be the strongest. We tested these predictions in five preregistered experiments using a reverse correlation paradigm. In Experiments 1-2, the facial representations resulting from an AAT looked more "approachable" and "avoidable," respectively. Specifically, we observed more bias on facial traits related to approach/avoidance (e.g., trustworthiness) than on traits less relevant for these actions (e.g., cleverness). Experiment 2 additionally tested the unique contribution of both approach and avoidance as compared to control actions. Experiments 3A-4 showed that this effect depends on experiencing the AAT (compared to the mere instructions of approach/avoidance) and on the sensory aspects of approach/avoidance that are mimicked in the AAT. Finally, Experiment 5 supported the idea that the AAT effect still emerges in the absence of explicit instructions of approach/avoidance (i.e., by only leaving the sensory aspects of approach/avoidance). The present research enriches the literature by revealing AAT effects that extend beyond mere evaluative consequences to the visual representation of the target stimuli. Our results also inform existing theoretical views on AAT effects. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Subject(s)
Avoidance Learning , Adult , Female , Humans , Male , Young Adult
19.
Acta Neuropathol ; 140(3): 317-339, 2020 09.
Article in English | MEDLINE | ID: mdl-32577828

ABSTRACT

Dysfunctional RNA-binding proteins (RBPs) have been implicated in several neurodegenerative disorders. Recently, this paradigm of RBPs has been extended to pathophysiology of Alzheimer's disease (AD). Here, we identified disease subtype specific variations in the RNA-binding proteome (RBPome) of sporadic AD (spAD), rapidly progressive AD (rpAD), and sporadic Creutzfeldt Jakob disease (sCJD), as well as control cases using RNA pull-down assay in combination with proteomics. We show that one of these identified proteins, splicing factor proline and glutamine rich (SFPQ), is downregulated in the post-mortem brains of rapidly progressive AD patients, sCJD patients and 3xTg mice brain at terminal stage of the disease. In contrast, the expression of SFPQ was elevated at early stage of the disease in the 3xTg mice, and in vitro after oxidative stress stimuli. Strikingly, in rpAD patients' brains SFPQ showed a significant dislocation from the nucleus and cytoplasmic colocalization with TIA-1. Furthermore, in rpAD brain lesions, SFPQ and p-tau showed extranuclear colocalization. Of note, association between SFPQ and tau-oligomers in rpAD brains suggests a possible role of SFPQ in oligomerization and subsequent misfolding of tau protein. In line with the findings from the human brain, our in vitro study showed that SFPQ is recruited into TIA-1-positive stress granules (SGs) after oxidative stress induction, and colocalizes with tau/p-tau in these granules, providing a possible mechanism of SFPQ dislocation through pathological SGs. Furthermore, the expression of human tau in vitro induced significant downregulation of SFPQ, suggesting a causal role of tau in the downregulation of SFPQ. The findings from the current study indicate that the dysregulation and dislocation of SFPQ, the subsequent DNA-related anomalies and aberrant dynamics of SGs in association with pathological tau represents a critical pathway which contributes to rapid progression of AD.


Subject(s)
Alzheimer Disease/metabolism , Brain/pathology , PTB-Associated Splicing Factor/metabolism , tau Proteins/metabolism , Alzheimer Disease/pathology , Animals , Brain/metabolism , Creutzfeldt-Jakob Syndrome/metabolism , Cytoplasm/metabolism , Down-Regulation/physiology , Humans , Mice, Transgenic , RNA-Binding Proteins/genetics , RNA-Binding Proteins/metabolism
20.
Behav Res Methods ; 52(4): 1800-1801, 2020 08.
Article in English | MEDLINE | ID: mdl-32128698

ABSTRACT

One of the two miscomputations identified in the infoVal metric, namely the omission of the k constant, turns out not to be a miscomputation, since the constant was already taken into account by default in the mad() function from R (see https://www.rdocumentation.org/packages/stats/versions/3.6.2/topics/mad ).

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